DPF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDPF2, REQ, UBID4, ubi-d4, double PHD fingers 2, CSS7, SMARCG2
External IDsOMIM: 601671 MGI: 109529 HomoloGene: 21265 GeneCards: DPF2
Orthologs
SpeciesHumanMouse
Entrez

5977

19708

Ensembl

ENSG00000133884

ENSMUSG00000024826

UniProt

Q92785

Q61103

RefSeq (mRNA)

NM_006268
NM_001330308

NM_001291078
NM_011262

RefSeq (protein)

NP_001317237
NP_006259
NP_006259.1

NP_001278007
NP_035392

Location (UCSC)Chr 11: 65.33 – 65.35 MbChr 19: 5.95 – 5.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein ubi-d4 is a protein that in humans is encoded by the DPF2 gene.[5][6]

The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000133884 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024826 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ninkina NN, Mertsalov IB, Kulikova DA, Alimova-Kost MV, Simonova OB, Korochkin LI, Kiselev SL, Buchman VL (Feb 2002). "Cerd4, third member of the d4 gene family: expression and organization of genomic locus". Mamm Genome. 12 (11): 862–6. doi:10.1007/s00335-001-3039-1. PMID 11845289. S2CID 2149578.
  6. 1 2 "Entrez Gene: DPF2 D4, zinc and double PHD fingers family 2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.