HOXB8
Identifiers
AliasesHOXB8, HOX2, HOX2D, Hox-2.4, homeobox B8
External IDsOMIM: 142963 MGI: 96189 HomoloGene: 7768 GeneCards: HOXB8
Orthologs
SpeciesHumanMouse
Entrez

3218

15416

Ensembl

ENSG00000120068

ENSMUSG00000056648

UniProt

P17481

P09632

RefSeq (mRNA)

NM_024016

NM_010461

RefSeq (protein)

NP_076921

NP_034591

Location (UCSC)Chr 17: 48.61 – 48.62 MbChr 11: 96.17 – 96.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.[5][6][7]

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of Homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog (see Homology (biology) § Orthology) of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the hair-pulling behavior of humans suffering from trichotillomania (TTM).[7]

Transplantation of normal (wild-type) bone marrow into a Hoxb8 mutant mouse results in a reduction of compulsive grooming.[8]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000120068 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056648 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
  7. 1 2 "Entrez Gene: HOXB8 homeobox B8".
  8. Chen SK, Tvrdik P, Peden E, Cho S, Wu S, Spangrude G, Capecchi MR (May 2010). "Hematopoietic origin of pathological grooming in Hoxb8 mutant mice". Cell. 141 (5): 775–85. doi:10.1016/j.cell.2010.03.055. PMC 2894573. PMID 20510925.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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