FOXO6
Identifiers
AliasesFOXO6, forkhead box O6
External IDsOMIM: 611457 MGI: 2676586 HomoloGene: 82395 GeneCards: FOXO6
Orthologs
SpeciesHumanMouse
Entrez

100132074

329934

Ensembl

ENSG00000204060
ENSG00000281518

ENSMUSG00000052135

UniProt

A0A1X9RU27

Q70KY4

RefSeq (mRNA)

NM_001291281

NM_194060

RefSeq (protein)

NP_001278210

NP_918949

Location (UCSC)Chr 1: 41.36 – 41.38 MbChr 4: 120.12 – 120.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Forkhead box O6 is a protein that in humans is encoded by the FOXO6 gene.[5]

FoxO6 is expressed in the liver, skeletal muscle, and the hippocampus of the brain.[6] In the liver, FoxO6 normally promotes gluconeogenesis in the fasted state, but insulin blocks Fox06 upon feeding.[6] In a condition of insulin resistance insulin fails to block FoxO6 resulting in continued gluconeogenesis even upon feeding.[6]

References

  1. 1 2 3 ENSG00000281518 GRCh38: Ensembl release 89: ENSG00000204060, ENSG00000281518 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052135 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Forkhead box O6".
  6. 1 2 3 Lee S, Dong HH (2017). "FoxO integration of insulin signaling with glucose and lipid metabolism". Journal of Endocrinology. 233 (2): R67–R79. doi:10.1530/JOE-17-0002. PMC 5480241. PMID 28213398.

Further reading

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