POU1F1
Identifiers
AliasesPOU1F1, CPHD1, GHF-1, PIT1, POU1F1a, Pit-1, POU class 1 homeobox 1
External IDsOMIM: 173110 MGI: 97588 HomoloGene: 259 GeneCards: POU1F1
Orthologs
SpeciesHumanMouse
Entrez

5449

18736

Ensembl

ENSG00000064835

ENSMUSG00000004842

UniProt

P28069

Q00286

RefSeq (mRNA)

NM_001122757
NM_000306

NM_008849
NM_001362468

RefSeq (protein)

NP_000297
NP_001116229

NP_032875
NP_001349397

Location (UCSC)Chr 3: 87.26 – 87.28 MbChr 16: 65.32 – 65.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

POU class 1 homeobox 1, also known as pituitary-specific positive transcription factor 1 (PIT1), POU domain, class 1, transcription factor 1 (POU1F1) and growth hormone factor 1 (GHF1), is a transcription factor for growth hormone encoded by the gene POU1F1.[5][6]

Function

PIT1 is part of the POU family of transcription factors.[7] It is expressed by somatotrophic cells,[8] as well as thyrotrophs[9] and lactotrophs[10] of the anterior pituitary gland. It contains a C-terminal domain for transactivation.[9] Another domain is DNA binding—its C-terminal portion is homologous to the homeodomain consensus,[8] common to many genes involved in development, while the other portion is POU specific, affords PIT1 specificity in its transcriptional activation of the prolactin and growth hormone genes and is involved in protein-protein interactions.[9] Activity on thyroid stimulating hormone-beta expression is also known for PIT1.[9]

Interactions

Pituitary-specific positive transcription factor 1 has been shown to interact with GATA2[11] and PITX1.[12]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000064835 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004842 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: POU1F1 POU class 1 homeobox 1 [ Homo sapiens (human) ]". National Library of Medicine, National Center for Biotechnology Information. 23 November 2023. Retrieved 2 January 2024.
  6. "Symbol report for POU1F1". HGNC. HUGO Gene Nomenclature Committee. 2023. Retrieved 2 January 2024.
  7. O'Neill, Marla J.F. (22 September 2021) [Originally authored by Victor A. McKusick on 13 January 1989]. "POU DOMAIN, CLASS 1, TRANSCRIPTION FACTOR 1; POU1F1". Online Mendelian Inheritance in Man. Retrieved 3 January 2024.
  8. 1 2 Bodner M, Castrillo JL, Theill LE, Deerinck T, Ellisman M, Karin M (1988). "The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein". Cell. 55 (3): 505–518. doi:10.1016/0092-8674(88)90037-2. PMID 2902927. S2CID 26376487.
  9. 1 2 3 4 Vallette-Kasic S, Pellegrini-Bouiller I, Sampieri F, Gunz G, Diaz A, Radovic S, Enjalbert A, Brue T (2001). "Combined Pituitary Hormone Deficiency due to the F135C Human Pit-1 (Pituitary-Specific Factor 1) Gene Mutation: Functional and Structural Correlates". Molecular Endocrinology. 15 (3): 411–420. doi:10.1210/mend.15.3.0601. PMID 11222742.
  10. Cohen LE, Wondisford FE, Radovick S (1996). "Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin". Endocrinology and Metabolism Clinics of North America. 25 (3): 523–540. doi:10.1016/s0889-8529(05)70339-x. PMID 8879985.
  11. Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG (May 1999). "Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types". Cell. 97 (5): 587–98. doi:10.1016/S0092-8674(00)80770-9. PMID 10367888. S2CID 15737684.
  12. Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG (July 1996). "P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7706–10. Bibcode:1996PNAS...93.7706S. doi:10.1073/pnas.93.15.7706. PMC 38811. PMID 8755540.

Further reading

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