NEUROD2
Identifiers
AliasesNEUROD2, NDRF, bHLHa1, neuronal differentiation 2, EIEE72, DEE72
External IDsOMIM: 601725 MGI: 107755 HomoloGene: 4489 GeneCards: NEUROD2
Orthologs
SpeciesHumanMouse
Entrez

4761

18013

Ensembl

ENSG00000171532

ENSMUSG00000038255

UniProt

Q15784

Q62414

RefSeq (mRNA)

NM_006160

NM_010895

RefSeq (protein)

NP_006151

NP_035025

Location (UCSC)Chr 17: 39.6 – 39.61 MbChr 11: 98.22 – 98.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.[5][6]

Function

This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.[6]

Interactions

NEUROD2 has been shown to interact with Protein kinase N1.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000171532 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038255 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Mar 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics. 40 (2): 355–7. doi:10.1006/geno.1996.4578. PMID 9119405.
  6. 1 2 "Entrez Gene: NEUROD2 neurogenic differentiation 2".
  7. Shibata H, Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y (Dec 1999). "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Research. Molecular Brain Research. 74 (1–2): 126–34. doi:10.1016/S0169-328X(99)00273-9. PMID 10640683.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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