ZNF426
Identifiers
AliasesZNF426, K-RBP, zinc finger protein 426
External IDsMGI: 1920248 HomoloGene: 23435 GeneCards: ZNF426
Orthologs
SpeciesHumanMouse
Entrez

79088

235028

Ensembl

ENSG00000130818

ENSMUSG00000059475

UniProt

Q9BUY5

Q8R1D1

RefSeq (mRNA)

NM_001300883
NM_024106
NM_001318055
NM_001318056

NM_001110309
NM_146221
NM_001310742

RefSeq (protein)

NP_001287812
NP_001304984
NP_001304985
NP_077011

NP_001103779
NP_001297671
NP_666333

Location (UCSC)Chr 19: 9.52 – 9.54 MbChr 9: 20.38 – 20.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 426 is a protein that in humans is encoded by the ZNF426 gene. [5]

Function

Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000130818 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059475 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Zinc finger protein 426". Retrieved 2016-01-28.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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