ZNF746
Identifiers
AliasesZNF746, P.A.R.I.S, PARIS, zinc finger protein 746
External IDsOMIM: 613914 MGI: 1916478 HomoloGene: 19783 GeneCards: ZNF746
Orthologs
SpeciesHumanMouse
Entrez

155061

69228

Ensembl

ENSG00000181220

ENSMUSG00000057691

UniProt

Q6NUN9

Q3U133

RefSeq (mRNA)

NM_001163474
NM_152557
NM_001363517
NM_001394198

NM_001163475
NM_001347142
NM_001362062

RefSeq (protein)

NP_001156946
NP_689770
NP_001350446

NP_001156947
NP_001334071
NP_001348991

Location (UCSC)Chr 7: 149.47 – 149.5 MbChr 6: 48.04 – 48.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 746 also known as Parkin-interacting substrate (PARIS) is a zinc finger protein that, in humans, is encoded by the ZNF746 gene and is involved in the neurodegeneration of Parkinson's disease.[5][6]


References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000181220 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057691 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shin JH, Ko HS, Kang H, Lee Y, Lee YI, Pletinkova O, et al. (March 2011). "PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease". Cell. 144 (5): 689–702. doi:10.1016/j.cell.2011.02.010. PMC 3063894. PMID 21376232.
  6. "Entrez Gene: ZNF746 zinc finger protein 746 [ Homo sapiens (human) ]".


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