ZMYND8

ZMYND8
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4COS
Identifiers
Aliases	ZMYND8, PRKCBP1, PRO2893, RACK7, zinc finger MYND-type containing 8
External IDs	OMIM: 615713 MGI: 1918025 HomoloGene: 32679 GeneCards: ZMYND8
Gene location (Human)
Chr.	Chromosome 20 (human)
End	47,356,889 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	165,740,936 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; oocyte; ; caput epididymis; ; pons; ; superior surface of tongue; ; superior vestibular nucleus; ; trigeminal ganglion; ; spongy bone; ; pylorus; ; middle temporal gyrus;
	Top expressed in
	medullary collecting duct; ; primitive streak; ; retinal pigment epithelium; ; urothelium; ; renal corpuscle; ; mucosa of urinary bladder; ; iris; ; facial motor nucleus; ; left lung lobe; ; yolk sac;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transcription corepressor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; chromatin binding; transcription coregulator activity; protein binding; metal ion binding; methylated histone binding; lysine-acetylated histone binding; protein N-terminus binding; zinc ion binding; protein domain specific binding;
Cellular component	cytoplasm; dendritic shaft; dendritic spine; nucleus;
Biological process	regulation of postsynaptic density protein 95 clustering; positive regulation of filopodium assembly; positive regulation of dendritic spine development; positive regulation of dendritic spine maintenance; modulation of excitatory postsynaptic potential; transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of cell migration; negative regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	23613
	228880
	ENSG00000101040
	ENSMUSG00000039671
	Q9ULU4
	n/a
NM_001281769; NM_001281771; NM_001281772; NM_001281773; NM_001281774;
	NM_001281775; NM_001281776; NM_001281777; NM_001281778; NM_001281779; NM_001281780; NM_001281781; NM_001281782; NM_001281783; NM_001281784; NM_012408; NM_183047; NM_183048; NM_001363714; NM_001363741
NM_001252584; NM_001252585; NM_001252587; NM_001281926; NM_001291158;
	NM_027230; NM_172270; NM_001363018; NM_001363019; NM_001363020; NM_001363021
NP_001268698; NP_001268700; NP_001268701; NP_001268702; NP_001268703;
	NP_001268704; NP_001268705; NP_001268706; NP_001268707; NP_001268708; NP_001268709; NP_001268710; NP_001268711; NP_001268712; NP_001268713; NP_036540; NP_898868; NP_898869; NP_001350643; NP_001350670
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase C-binding protein 1 is an enzyme that in humans is encoded by the ZMYND8 gene.^[5]

The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101040 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039671 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: ZMYND8 zinc finger, MYND-type containing 8".

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Fossey SC; Kuroda S; Price JA; et al. (2000). "Identification and characterization of PRKCBP1, a candidate RACK-like protein". Mamm. Genome. 11 (10): 919–25. doi:10.1007/s003350010174. PMID 11003709. S2CID 646555.
Eichmuller S; Usener D; Dummer R; et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
Deloukas P; Matthews LH; Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
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Beausoleil SA; Jedrychowski M; Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Miles RR, Crockett DK, Lim MS, Elenitoba-Johnson KS (2006). "Analysis of BCL6-interacting proteins by tandem mass spectrometry". Mol. Cell. Proteomics. 4 (12): 1898–909. doi:10.1074/mcp.M500112-MCP200. PMID 16147992.
Lim J; Hao T; Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Olsen JV; Blagoev B; Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000101040 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039671 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: ZMYND8 zinc finger, MYND-type containing 8".

[1]

[2]

[3]

[4]

[5]

References

Further reading