XAF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesXAF1, BIRC4BP, HSXIAPAF1, XIAPAF1, XIAP associated factor 1
External IDsOMIM: 606717 MGI: 3772572 HomoloGene: 49488 GeneCards: XAF1
Orthologs
SpeciesHumanMouse
Entrez

54739

327959

Ensembl

ENSG00000132530

ENSMUSG00000040483

UniProt

Q6GPH4

Q5NBU8

RefSeq (mRNA)

NM_001037713
NM_001291153

RefSeq (protein)

NP_001032802
NP_001278082

Location (UCSC)Chr 17: 6.76 – 6.78 MbChr 11: 72.19 – 72.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

XIAP-associated factor 1 is a protein that in humans is encoded by the XAF1 gene.[5][6][7]

Function

X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells (Liston et al., 2001).[supplied by OMIM][7]

Interactions

XAF1 has been shown to interact with XIAP.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000132530 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040483 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Leaman DW, Chawla-Sarkar M, Vyas K, Reheman M, Tamai K, Toji S, Borden EC (Aug 2002). "Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis". J. Biol. Chem. 277 (32): 28504–11. doi:10.1074/jbc.M204851200. PMID 12029096.
  6. 1 2 Liston P, Fong WG, Kelly NL, Toji S, Miyazaki T, Conte D, Tamai K, Craig CG, McBurney MW, Korneluk RG (Feb 2001). "Identification of XAF1 as an antagonist of XIAP anti-Caspase activity". Nat. Cell Biol. 3 (2): 128–33. doi:10.1038/35055027. PMID 11175744. S2CID 19731886.
  7. 1 2 "Entrez Gene: XAF1 XIAP associated factor-1".

Further reading


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