WDR4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWDR4, TRM82, TRMT82, WD repeat domain 4, GAMOS6, MIGSB, hWH, Wuho
External IDsOMIM: 605924 MGI: 1889002 HomoloGene: 32422 GeneCards: WDR4
Orthologs
SpeciesHumanMouse
Entrez

10785

57773

Ensembl

ENSG00000160193

ENSMUSG00000024037

UniProt

P57081

Q9EP82

RefSeq (mRNA)

NM_021322

RefSeq (protein)

NP_067297

Location (UCSC)Chr 21: 42.84 – 42.88 MbChr 17: 31.71 – 31.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 is an enzyme subunit that in humans is encoded by the WDR4 gene.[5]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.

This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Two transcript variants encoding the same protein have been found for this gene.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000160193 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024037 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: WDR4 WD repeat domain 4".

Further reading


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