VPS45
Identifiers
AliasesVPS45, H1, H1SCN5, VPS45A, VPS45B, VPS54A, VSP45, VSP45A, vacuolar protein sorting 45 homolog
External IDsOMIM: 610035 MGI: 891965 HomoloGene: 5250 GeneCards: VPS45
Orthologs
SpeciesHumanMouse
Entrez

11311

22365

Ensembl

ENSG00000136631

ENSMUSG00000015747

UniProt

Q9NRW7

P97390

RefSeq (mRNA)

NM_001279353
NM_001279354
NM_001279355
NM_007259

NM_013841

RefSeq (protein)

NP_001266282
NP_001266283
NP_009190

NP_038869

Location (UCSC)Chr 1: 150.07 – 150.15 MbChr 3: 95.91 – 95.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vacuolar protein sorting-associated protein 45 is a protein that in humans is encoded by the VPS45 gene.[5][6]

Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000136631 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015747 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pevsner J, Hsu SC, Hyde PS, Scheller RH (Feb 1997). "Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking". Gene. 183 (1–2): 7–14. doi:10.1016/S0378-1119(96)00367-8. PMID 8996080.
  6. 1 2 "Entrez Gene: VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)".

Further reading


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