CHMP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCHMP3, NEDF, VPS24, CGI-149, charged multivesicular body protein 3
External IDsOMIM: 610052 MGI: 1913950 HomoloGene: 6368 GeneCards: CHMP3
Orthologs
SpeciesHumanMouse
Entrez

51652

66700

Ensembl

ENSG00000115561

ENSMUSG00000053119

UniProt

Q9Y3E7

Q9CQ10

RefSeq (mRNA)

NM_001005753
NM_001193517
NM_016079

NM_025783
NM_001355674
NM_001355675
NM_001361405

RefSeq (protein)

NP_001005753
NP_001180446
NP_057163

NP_080059
NP_001342603
NP_001342604
NP_001348334

Location (UCSC)Chr 2: 86.5 – 86.56 MbChr 6: 71.52 – 71.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.[5][6][7]

Function

This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.[7]

Interactions

VPS24 has been shown to interact with IGFBP7.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000115561 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053119 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Wilson EM, Oh Y, Hwa V, Rosenfeld RG (Sep 2001). "Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells". J Clin Endocrinol Metab. 86 (9): 4504–11. doi:10.1210/jcem.86.9.7845. PMID 11549700.
  6. Whitley P, Reaves BJ, Hashimoto M, Riley AM, Potter BV, Holman GD (Sep 2003). "Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization". J Biol Chem. 278 (40): 38786–95. doi:10.1074/jbc.M306864200. PMID 12878588.
  7. 1 2 "Entrez Gene: VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae)".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.