TWF1

TWF1
Identifiers
Aliases	TWF1, A6, PTK9, twinfilin actin binding protein 1
External IDs	OMIM: 610932 MGI: 1100520 HomoloGene: 48140 GeneCards: TWF1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	43,806,328 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	94,487,770 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; palpebral conjunctiva; ; seminal vesicula; ; Achilles tendon; ; cavity of mouth; ; jejunal mucosa; ; islet of Langerhans; ; rectum; ; human penis; ; external globus pallidus;
	Top expressed in
	utricle; ; Paneth cell; ; cumulus cell; ; olfactory epithelium; ; ileum; ; stria vascularis; ; yolk sac; ; jejunum; ; cervix; ; large intestine;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; protein tyrosine kinase activity; ATP binding; actin monomer binding; phosphatidylinositol-4,5-bisphosphate binding; cadherin binding; actin binding; protein binding; actin filament binding;
Cellular component	intracellular anatomical structure; cytoskeleton; focal adhesion; filopodium; actin cytoskeleton; cell-cell junction; perinuclear region of cytoplasm; myofibril; ruffle membrane; cytoplasm; cytosol; actin filament;
Biological process	regulation of actin phosphorylation; barbed-end actin filament capping; sequestering of actin monomers; negative regulation of actin filament polymerization; positive regulation of cardiac muscle hypertrophy; regulation of lamellipodium assembly; positive regulation of neuron projection development; peptidyl-tyrosine phosphorylation; actin filament depolymerization;
	Sources:Amigo / QuickGO
Orthologs
	5756
	19230
	ENSG00000151239
	ENSMUSG00000022451
	Q12792
	Q91YR1
	NM_001242397; NM_002822; NM_198974
	NM_008971
	NP_001229326; NP_002813
	NP_032997; NP_001389738; NP_001389739
	Wikidata
View/Edit Human	View/Edit Mouse

Twinfilin-1 is a protein that in humans is encoded by the TWF1 gene.^[5]^[6] This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000151239 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022451 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Beeler JF, LaRochelle WJ, Chedid M, Tronick SR, Aaronson SA (February 1994). "Prokaryotic expression cloning of a novel human tyrosine kinase". Mol. Cell. Biol. 14 (2): 982–8. doi:10.1128/mcb.14.2.982. PMC 358453. PMID 7507208.
1 2 "Entrez Gene: TWF1 twinfilin, actin-binding protein, homolog 1 (Drosophila)".

Palmgren S, Vartiainen M, Lappalainen P (2002). "Twinfilin, a molecular mailman for actin monomers". J. Cell Sci. 115 (Pt 5): 881–6. doi:10.1242/jcs.115.5.881. PMID 11870207.
Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402. S2CID 6773754.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Vartiainen MK, Sarkkinen EM, Matilainen T, et al. (2003). "Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated". J. Biol. Chem. 278 (36): 34347–55. doi:10.1074/jbc.M303642200. PMID 12807912.
Galey D, Becker K, Haughey N, et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". J. Neurovirol. 9 (3): 358–71. doi:10.1080/13550280390201119. PMID 12775419. S2CID 22016092.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ojala PJ, Paavilainen VO, Vartiainen MK, et al. (2003). "The two ADF-H domains of twinfilin play functionally distinct roles in interactions with actin monomers". Mol. Biol. Cell. 13 (11): 3811–21. doi:10.1091/mbc.E02-03-0157. PMC 133594. PMID 12429826.
Paavilainen VO, Merckel MC, Falck S, et al. (2003). "Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin". J. Biol. Chem. 277 (45): 43089–95. doi:10.1074/jbc.M208225200. PMID 12207032.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000151239 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022451 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7507208-5] Beeler JF, LaRochelle WJ, Chedid M, Tronick SR, Aaronson SA (February 1994). "Prokaryotic expression cloning of a novel human tyrosine kinase". Mol. Cell. Biol. 14 (2): 982–8. doi:10.1128/mcb.14.2.982. PMC 358453. PMID 7507208.

[entrez-6] 1 2 "Entrez Gene: TWF1 twinfilin, actin-binding protein, homolog 1 (Drosophila)".

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References

Further reading