TCEA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTCEA1, GTF2S, SII, TCEA, TF2S, TFIIS, transcription elongation factor A1
External IDsOMIM: 601425 MGI: 1196624 HomoloGene: 55984 GeneCards: TCEA1
Orthologs
SpeciesHumanMouse
Entrez

6917

21399

Ensembl

ENSG00000187735

ENSMUSG00000033813

UniProt

P23193

P10711

RefSeq (mRNA)

NM_006756
NM_201437

NM_001159750
NM_001159751
NM_011541

RefSeq (protein)

NP_006747
NP_958845

NP_001153222
NP_001153223
NP_035671

Location (UCSC)Chr 8: 53.97 – 54.02 MbChr 1: 4.93 – 4.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene.[5][6][7]

In other organisms, this gene is better known as transcription elongation factor II S (TFIIS). It mainly helps to resolve backtracked elongation complexes by inducing a cut in the RNAP active site, so reaction becomes possible again. It is also found in the eukaryotic transcription preinitiation complex.[8] A homolog in archaea performs the same main task, while bacteria use the non-homologous Gre.[9]

Interactions

TCEA1 has been shown to interact with GTF2H1[10][11] and POLR2A.[10][11][12]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000187735 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033813 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. DiMarco SP, Glover TW, Miller DE, Reines D, Warren ST (August 1996). "Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --> p21.3". Genomics. 36 (1): 185–8. doi:10.1006/geno.1996.0443. PMID 8812434.
  6. Park H, Baek K, Jeon C, Agarwal K, Yoo O (February 1994). "Characterization of the gene encoding the human transcriptional elongation factor TFIIS". Gene. 139 (2): 263–7. doi:10.1016/0378-1119(94)90767-6. PMID 8112616.
  7. "Entrez Gene: TCEA1 transcription elongation factor A (SII), 1".
  8. Kim B, Nesvizhskii AI, Rani PG, Hahn S, Aebersold R, Ranish JA (October 2007). "The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes". Proceedings of the National Academy of Sciences of the United States of America. 104 (41): 16068–73. Bibcode:2007PNAS..10416068K. doi:10.1073/pnas.0704573104. PMC 2042163. PMID 17913884.
  9. Robinson NP, Fouqueau T, Blombach F, Cackett G, Carty AE, Matelska DM, Ofer S, Pilotto S, Phung DK, Werner F (14 December 2018). "The cutting edge of archaeal transcription". Emerging Topics in Life Sciences. 2 (4): 517–533. doi:10.1042/ETLS20180014. PMC 7289017. PMID 33525828.
  10. 1 2 Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, et al. (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". The Journal of Biological Chemistry. 273 (42): 27593–601. doi:10.1074/jbc.273.42.27593. PMID 9765293.
  11. 1 2 Pan G, Aso T, Greenblatt J (September 1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators". The Journal of Biological Chemistry. 272 (39): 24563–71. doi:10.1074/jbc.272.39.24563. PMID 9305922.
  12. Kettenberger H, Armache KJ, Cramer P (August 2003). "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage". Cell. 114 (3): 347–57. doi:10.1016/S0092-8674(03)00598-1. hdl:11858/00-001M-0000-0015-8647-8. PMID 12914699. S2CID 17184533.

Further reading

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