SFN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSFN, YWHAS, Stratifin
External IDsOMIM: 601290 MGI: 1891831 HomoloGene: 4475 GeneCards: SFN
Orthologs
SpeciesHumanMouse
Entrez

2810

55948

Ensembl

ENSG00000175793

ENSMUSG00000047281

UniProt

P31947

O70456

RefSeq (mRNA)

NM_006142

NM_018754

RefSeq (protein)

NP_006133

NP_061224

Location (UCSC)Chr 1: 26.86 – 26.86 MbChr 4: 133.33 – 133.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a protein encoded by the SFN gene in humans.[5][6] The protein is named for its presence in stratified epithelial cells.[5]


Interactions

Stratifin has been shown to interact with PLK4,[7] ERRFI1,[8] MARK3,[7][8] JUB[8] and YWHAG.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000175793 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047281 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Leffers H, Madsen P, Rasmussen HH, Honoré B, Andersen AH, Walbum E, Vandekerckhove J, Celis JE (June 1993). "Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway". Journal of Molecular Biology. 231 (4): 982–98. doi:10.1006/jmbi.1993.1346. PMID 8515476.
  6. "Entrez Gene: SFN stratifin".
  7. 1 2 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  8. 1 2 3 4 Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.

Further reading


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