SUPT16H
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSUPT16H, CDC68, FACTP140, SPT16/CDC68, SPT16, SPT16 homolog, facilitates chromatin remodeling subunit, NEDDFAC
External IDsOMIM: 605012 MGI: 1890948 HomoloGene: 5207 GeneCards: SUPT16H
Orthologs
SpeciesHumanMouse
Entrez

11198

114741

Ensembl

ENSG00000092201

ENSMUSG00000035726

UniProt

Q9Y5B9

Q920B9

RefSeq (mRNA)

NM_007192

NM_033618

RefSeq (protein)

NP_009123

NP_291096

Location (UCSC)Chr 14: 21.35 – 21.38 MbChr 14: 52.4 – 52.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FACT complex subunit SPT16 is a protein that in humans is encoded by the SUPT16H gene.[5][6][7]

Function

Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit, the latter of which is the protein encoded by this gene.[7]

Interactions

SUPT16H has been shown to interact with BAZ1B.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000092201 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035726 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Orphanides G, LeRoy G, Chang CH, Luse DS, Reinberg D (Mar 1998). "FACT, a factor that facilitates transcript elongation through nucleosomes". Cell. 92 (1): 105–16. doi:10.1016/S0092-8674(00)80903-4. PMID 9489704.
  6. Keller DM, Zeng X, Wang Y, Zhang QH, Kapoor M, Shu H, Goodman R, Lozano G, Zhao Y, Lu H (Mar 2001). "A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1". Mol Cell. 7 (2): 283–92. doi:10.1016/S1097-2765(01)00176-9. PMID 11239457.
  7. 1 2 "Entrez Gene: SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)".
  8. Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (Jun 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q9Y5B9 (FACT complex subunit SPT16) at the PDBe-KB.
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