SOCS5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSOCS5, CIS6, CISH6, Cish5, SOCS-5, suppressor of cytokine signaling 5
External IDsOMIM: 607094 MGI: 2385459 HomoloGene: 10495 GeneCards: SOCS5
Orthologs
SpeciesHumanMouse
Entrez

9655

56468

Ensembl

ENSG00000171150

ENSMUSG00000037104

UniProt

O75159

O54928

RefSeq (mRNA)

NM_144949
NM_014011

NM_019654

RefSeq (protein)

NP_054730
NP_659198

NP_062628

Location (UCSC)Chr 2: 46.7 – 46.78 MbChr 17: 87.42 – 87.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene.[5][6][7]

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000171150 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037104 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  7. 1 2 "Entrez Gene: SOCS5 suppressor of cytokine signaling 5".

Further reading


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