SOAT2
Identifiers
AliasesSOAT2, ACACT2, ACAT2, ARGP2, sterol O-acyltransferase 2
External IDsOMIM: 601311 MGI: 1332226 HomoloGene: 68355 GeneCards: SOAT2
Orthologs
SpeciesHumanMouse
Entrez

8435

223920

Ensembl

ENSG00000167780

ENSMUSG00000023045

UniProt

O75908

O88908

RefSeq (mRNA)

NM_003578

NM_146064

RefSeq (protein)

NP_003569

NP_666176

Location (UCSC)Chr 12: 53.1 – 53.12 MbChr 15: 102.06 – 102.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sterol O-acyltransferase 2, also known as SOAT2, is an enzyme that in humans is encoded by the SOAT2 gene.[5]

Function

This gene is a member of a small family of Acyl-CoA:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very-low-density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000167780 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023045 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: SOAT2 sterol O-acyltransferase 2".

Further reading


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