SLK
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSLK, LOSK, STK2, bA16H23.1, se20-9, STE20 like kinase
External IDsOMIM: 616563 MGI: 103241 HomoloGene: 22515 GeneCards: SLK
Orthologs
SpeciesHumanMouse
Entrez

9748

20874

Ensembl

ENSG00000065613

ENSMUSG00000025060

UniProt

Q9H2G2

O54988

RefSeq (mRNA)

NM_001304743
NM_014720

NM_001164639
NM_009289

RefSeq (protein)

NP_001291672
NP_055535

NP_001158111
NP_033315

Location (UCSC)Chr 10: 103.97 – 104.03 MbChr 19: 47.57 – 47.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

STE20-like serine/threonine-protein kinase is an enzyme that in humans is encoded by the SLK gene.[5][6]

Interactions

SLK (gene) has been shown to interact with PDZK1.[7]

SLK is a mammalian gene located on chromosome 10. it has also been cloned in rats.[8] There is a whole family of STE20 like protein kinases, which has been divided into three categories. the most important p21-activated kinase (PAK), germinal center kinases (GCK) and Pleckstrin homology domain containing PAK (PHPAK).[9] SLK gene plays an important role in development, termination and differentiation of cells and tissues. the main enzyme SLK gene produces is called Ste20-like kinases which was formerly known as Ste20-like serine/threonine protein kinase. the balanced expression of SLK gene is very essential for the correct development of body parts in all mammals. this enzyme is also involved in cell movement and cell cycle. The expression of SLK gene in germ line cell is regulated by phosphorylation of PLK1, which is another gene involved in mitosis. Ste20- like kinases manages the correct orientation of micro-tubules during inter-phase level of cell cycles. Underproduction of Ste20-like serine/threonine-protein kinases can result in micro-tubule fibers to detach from chromosomes. It also functions in activation/deactivation of apoptosis in cells, as well as organization and adhesion of cell to shape an appropriate organ.

[10][11]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000065613 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025060 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Celenza JL, Carlson M (Sep 1986). "A yeast gene that is essential for release from glucose repression encodes a protein kinase". Science. 233 (4769): 1175–80. Bibcode:1986Sci...233.1175C. doi:10.1126/science.3526554. PMID 3526554.
  6. "Entrez Gene: SLK STE20-like kinase (yeast)".
  7. Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
  8. Ste20-like kinases SLK, at the crossroad
  9. Al‐Zahrani, Sekhon. “Essential Role for the SLK Protein Kinase in Embryogenesis and Placental Tissue Development.” Developmental Dynamics, vol. 243, no. 5, Wiley Subscription Services, Inc, May 2014, pp. 640–51, doi:10.1002/dvdy.24106
  10. Cybulsky, Papillon. “Ste20-Like Kinase, SLK, a Novel Mediator of Podocyte Integrity.” American Journal of Physiology. Renal Physiology, vol. 315, no. 1, American Physiological Society, July 2018, pp. F186–F198, doi:10.1152/ajprenal.00238.2017
  11. Cybulsky, Takano. “The Ste20-Like Kinase SLK Promotes P53 Transactivation and Apoptosis.” American Journal of Physiology. Renal Physiology 297.4 (2009): 971–980. Web

Further reading


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