SGSM2
Identifiers
AliasesSGSM2, RUTBC1, small G protein signaling modulator 2
External IDsOMIM: 611418 MGI: 2144695 HomoloGene: 14780 GeneCards: SGSM2
Orthologs
SpeciesHumanMouse
Entrez

9905

97761

Ensembl

ENSG00000141258

ENSMUSG00000038351

UniProt

O43147

Q80U12

RefSeq (mRNA)

NM_001098509
NM_014853
NM_001346700

NM_197943
NM_001374688

RefSeq (protein)

NP_001091979
NP_001333629
NP_055668

NP_922934
NP_001361617

Location (UCSC)Chr 17: 2.34 – 2.38 MbChr 11: 74.74 – 74.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Small G protein signaling modulator 2 is a protein that in humans is encoded by the SGSM2 gene.[5][6]

Clinical relevance

In a recent genome-wide association study, this gene has been associated with fasting glucose traits, type 2 diabetes and obesity.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000141258 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038351 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yang, H; et al. (2007). "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway". Genomics. 90 (2): 249–260. doi:10.1016/j.ygeno.2007.03.013. PMID 17509819.
  6. "Entrez Gene: small G protein signaling modulator 2".
  7. Strawbridge, RJ; et al. (2011-08-26). "Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes". Diabetes. 60 (10): 2624–34. doi:10.2337/db11-0415. PMC 3178302. PMID 21873549.

Further reading


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