RTL3

RTL3
Identifiers
Aliases	RTL3, Mar3, Mart3, ZHC5, ZCCHC5, zinc finger CCHC-type containing 5, SIRH9, retrotransposon Gag like 3
External IDs	MGI: 2685221 HomoloGene: 19397 GeneCards: RTL3
Gene location (Human)
Chr.	X chromosome (human)
End	78,659,328 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	105,884,250 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; right coronary artery; ; ascending aorta; ; tibia; ; Achilles tendon; ; smooth muscle tissue; ; popliteal artery; ; left coronary artery; ; synovial membrane; ; saphenous vein;
	Top expressed in
	dermis; ; condyle; ; internal carotid artery; ; external carotid artery; ; atrioventricular valve; ; fossa; ; belly cord; ; endocardial cushion; ; esophagus; ; calvaria;
	More reference expression data
	n/a
Orthologs
	203430
	213436
	ENSG00000179300
	ENSMUSG00000047686
	Q8N8U3
	Q6P1Y1
	NM_152694
	NM_199468
	NP_689907
	NP_955762
	Wikidata
View/Edit Human	View/Edit Mouse

Retrotransposon Gag like 3 is a protein that in humans is encoded by the RTL3 gene. ^[5]

Function

This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell. Retrotransposon gag-like-3 (RTL3/ZCCHC5/MART3) is one of eleven Sushi-like neogenes identified in the human genome7 RTL3 encodes a 53 kDa protein with a nucleic acid-binding domain (CX2CX4HX4C), gag-like region within the open reading frame and an ssDNA/RNA-binding homeobox-associated leucine zipper motif.^[6] It has been reported that RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000179300 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047686 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Retrotransposon Gag like 3". Retrieved 2017-09-18.
1 2 Ball HC, Ansari MY, Ahmad N, Novak K, Haqqi TM (November 2021). "A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes". Connective Tissue Research. 62 (6): 615–628. doi:10.1080/03008207.2020.1828380. PMC 8404968. PMID 33043724.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000179300 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047686 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Retrotransposon Gag like 3". Retrieved 2017-09-18.

[Ball_2021-6] 1 2 Ball HC, Ansari MY, Ahmad N, Novak K, Haqqi TM (November 2021). "A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes". Connective Tissue Research. 62 (6): 615–628. doi:10.1080/03008207.2020.1828380. PMC 8404968. PMID 33043724.

[1]

[2]

[3]

[4]

[5]

[6]