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Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) is a protein that in humans is encoded by the RTF1 gene.[1]
This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA.[1]
References
- 1 2 "Entrez Gene: Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)". Retrieved 2011-09-20.
Further reading
- Rozenblatt-Rosen, O.; Hughes, C. M.; Nannepaga, S. J.; Shanmugam, K. S.; Copeland, T. D.; Guszczynski, T.; Resau, J. H.; Meyerson, M. (2005). "The Parafibromin Tumor Suppressor Protein is Part of a Human Paf1 Complex". Molecular and Cellular Biology. 25 (2): 612–620. doi:10.1128/MCB.25.2.612-620.2005. PMC 543415. PMID 15632063.
- Warner, M. H.; Roinick, K. L.; Arndt, K. M. (2007). "Rtf1 is a Multifunctional Component of the Paf1 Complex That Regulates Gene Expression by Directing Cotranscriptional Histone Modification". Molecular and Cellular Biology. 27 (17): 6103–6115. doi:10.1128/MCB.00772-07. PMC 1952162. PMID 17576814.
- De Jong, R. N.; Truffault, V.; Diercks, T.; Ab, E.; Daniels, M. A.; Kaptein, R.; Folkers, G. E. (2008). "Structure and DNA Binding of the Human Rtf1 Plus3 Domain". Structure. 16 (1): 149–159. doi:10.1016/j.str.2007.10.018. hdl:1874/33204. PMID 18184592. S2CID 38494347.
- Nordick, K.; Hoffman, M. G.; Betz, J. L.; Jaehning, J. A. (2008). "Direct Interactions between the Paf1 Complex and a Cleavage and Polyadenylation Factor Are Revealed by Dissociation of Paf1 from RNA Polymerase II". Eukaryotic Cell. 7 (7): 1158–1167. doi:10.1128/EC.00434-07. PMC 2446681. PMID 18469135.
- Lango Allen, H.; Estrada, K.; Lettre, G.; Berndt, S. I.; Weedon, M. N.; Rivadeneira, F.; Willer, C. J.; Jackson, A. U.; Vedantam, S.; Raychaudhuri, S.; Ferreira, T.; Wood, A. R.; Weyant, R. J.; Segrè, A. V.; Speliotes, E. K.; Wheeler, E.; Soranzo, N.; Park, J. H.; Yang, J.; Gudbjartsson, D.; Heard-Costa, N. L.; Randall, J. C.; Qi, L.; Vernon Smith, A.; Mägi, R.; Pastinen, T.; Liang, L.; Heid, I. M.; Luan, J. A.; et al. (2010). "Hundreds of variants clustered in genomic loci and biological pathways affect human height". Nature. 467 (7317): 832–838. Bibcode:2010Natur.467..832L. doi:10.1038/nature09410. PMC 2955183. PMID 20881960.
- Nagase, T.; Seki, N.; Ishikawa, K.; Ohira, M.; Kawarabayasi, Y.; Ohara, O.; Tanaka, A.; Kotani, H.; Miyajima, N.; Nomura, N. (1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–329, 341–329. doi:10.1093/dnares/3.5.321. PMID 9039502.
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