PLPP2
Identifiers
AliasesPLPP2, LPP2, PAP-2c, PAP2-g, PPAP2C, Phosphatidic acid phosphatase 2c, phospholipid phosphatase 2
External IDsOMIM: 607126 MGI: 1354945 HomoloGene: 2752 GeneCards: PLPP2
Orthologs
SpeciesHumanMouse
Entrez

8612

50784

Ensembl

ENSG00000141934

ENSMUSG00000052151

UniProt

O43688

Q9DAX2

RefSeq (mRNA)

NM_003712
NM_177526
NM_177543

NM_015817
NM_001302389
NM_001302390
NM_001302442

RefSeq (protein)

NP_003703
NP_803545
NP_808211

NP_001289318
NP_001289319
NP_001289371
NP_056632

Location (UCSC)Chr 19: 0.28 – 0.29 MbChr 10: 79.36 – 79.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lipid phosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the PPAP2C gene.[5][6][7]

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000141934 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052151 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Leung DW, Tompkins CK, White T (May 1998). "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells". DNA Cell Biol. 17 (4): 377–85. doi:10.1089/dna.1998.17.377. PMID 9570154.
  6. Hooks SB, Ragan SP, Lynch KR (Jun 1998). "Identification of a novel human phosphatidic acid phosphatase type 2 isoform". FEBS Lett. 427 (2): 188–92. doi:10.1016/S0014-5793(98)00421-9. PMID 9607309. S2CID 31610109.
  7. 1 2 "Entrez Gene: PPAP2C phosphatidic acid phosphatase type 2C".

Further reading

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