PRPSAP2

PRPSAP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JI4
Identifiers
Aliases	PRPSAP2, PAP41, phosphoribosyl pyrophosphate synthetase associated protein 2
External IDs	OMIM: 603762 MGI: 2384838 HomoloGene: 2073 GeneCards: PRPSAP2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	18,931,287 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	61,652,914 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; cerebellar hemisphere; ; pons; ; lymph node; ; inferior ganglion of vagus nerve; ; corpus callosum; ; thymus; ; pituitary gland; ; islet of Langerhans; ; subthalamic nucleus;
	Top expressed in
	secondary oocyte; ; ganglionic eminence; ; morula; ; lens; ; blastocyst; ; spermatocyte; ; mesencephalon; ; hypothalamus; ; olfactory bulb; ; spleen;
	More reference expression data
	n/a
Gene ontology
Molecular function	ribose phosphate diphosphokinase activity; enzyme inhibitor activity; magnesium ion binding; protein binding; enzyme regulator activity;
Cellular component	ribose phosphate diphosphokinase complex; cytoplasm; protein-containing complex;
Biological process	nucleotide biosynthetic process; bone development; nucleobase-containing compound metabolic process; negative regulation of catalytic activity; nucleoside metabolic process; 5-phosphoribose 1-diphosphate biosynthetic process; purine nucleotide biosynthetic process; regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	5636
	212627
	ENSG00000141127
	ENSMUSG00000020528
	O60256
	Q8R574
NM_001243936; NM_001243940; NM_001243941; NM_001243942; NM_002767;
	NM_001353096; NM_001353097; NM_001353098; NM_001353099; NM_001353100; NM_001353101; NM_001353102; NM_001353103; NM_001353104; NM_001353105; NM_001353106; NM_001353107
NM_001164242; NM_001164243; NM_001164244; NM_144806; NM_001364086;
	NM_001364087; NM_001364088; NM_001364090
NP_001230865; NP_001230869; NP_001230870; NP_001230871; NP_002758;
	NP_001340025; NP_001340026; NP_001340027; NP_001340028; NP_001340029; NP_001340030; NP_001340031; NP_001340032; NP_001340033; NP_001340034; NP_001340035; NP_001340036
NP_001157714; NP_001157715; NP_001157716; NP_659055; NP_001351015;
	NP_001351016; NP_001351017; NP_001351019
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoribosyl pyrophosphate synthetase-associated protein 2 is a protein that in humans is encoded by the PRPSAP2 gene.^[5]

Function

The enzyme phosphoribosyl pyrophosphate synthetase (PRS) catalyzes the formation of phosphoribosyl pyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000141127 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020528 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: phosphoribosyl pyrophosphate synthetase-associated protein 2". Retrieved 2011-08-30.

Katashima R, Iwahana H, Fujimura M, et al. (1998). "Molecular cloning of a human cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein". Biochim. Biophys. Acta. 1396 (3): 245–50. doi:10.1016/S0167-4781(97)00217-0. PMID 9545573.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Katashima R, Iwahana H, Fujimura M, et al. (1998). "Assignment of the human phosphoribosylpyrophosphate synthetase-associated protein 41 gene (PRPSAP2) to 17p11.2-p12". Genomics. 54 (1): 180–1. doi:10.1006/geno.1998.5432. PMID 9806849.
Low SK, Kuchiba A, Zembutsu H, et al. (2010). "Genome-wide association study of pancreatic cancer in Japanese population". PLOS ONE. 5 (7): e11824. Bibcode:2010PLoSO...511824L. doi:10.1371/journal.pone.0011824. PMC 2912284. PMID 20686608.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000141127 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020528 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: phosphoribosyl pyrophosphate synthetase-associated protein 2". Retrieved 2011-08-30.

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Function

References

Further reading