PPP1R10
Identifiers
AliasesPPP1R10, CAT53, FB19, PNUTS, PP1R10, R111, p99, protein phosphatase 1 regulatory subunit 10
External IDsOMIM: 603771 MGI: 1289273 HomoloGene: 2033 GeneCards: PPP1R10
Orthologs
SpeciesHumanMouse
Entrez

5514

52040

Ensembl

ENSMUSG00000039220

UniProt

Q96QC0

Q80W00

RefSeq (mRNA)

NM_002714
NM_001376195

NM_001163818
NM_175934
NM_001357740

RefSeq (protein)

NP_002705
NP_001363124

NP_001157290
NP_001344669
NP_001390493

Location (UCSC)Chr 6: 30.6 – 30.62 MbChr 17: 36.23 – 36.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase 1 regulatory subunit 10 is an enzyme that in humans is encoded by the PPP1R10 gene. This gene lies within the major histocompatibility complex class I region on chromosome 6.[5][6][7]

Function

This gene encodes a protein with similarity to a rat protein that has an inhibitory effect on protein phosphatase-1 (PP1). The rat protein localizes to the nucleus and colocalizes with chromatin at distinct phases during mitosis.[7]

References

  1. 1 2 3 ENSG00000238104, ENSG00000206489, ENSG00000230995, ENSG00000235291, ENSG00000231737, ENSG00000204569 GRCh38: Ensembl release 89: ENSG00000227804, ENSG00000238104, ENSG00000206489, ENSG00000230995, ENSG00000235291, ENSG00000231737, ENSG00000204569 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039220 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Allen PB, Kwon YG, Nairn AC, Greengard P (Mar 1998). "Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit". J Biol Chem. 273 (7): 4089–95. doi:10.1074/jbc.273.7.4089. PMID 9461602.
  6. Totaro A, Grifa A, Carella M, Rommens JM, Valentino MA, Roetto A, Zelante L, Gasparini P (Nov 1998). "Cloning of a new gene (FB19) within HLA class I region". Biochem Biophys Res Commun. 250 (3): 555–7. doi:10.1006/bbrc.1998.9354. PMID 9784381.
  7. 1 2 "Entrez Gene: PPP1R10 protein phosphatase 1, regulatory (inhibitor) subunit 10".

Further reading


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