PPIL3

PPIL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XYH, 2OJU, 2OK3
Identifiers
Aliases	PPIL3, CYPJ, peptidylprolyl isomerase like 3
External IDs	OMIM: 615811 MGI: 1917475 HomoloGene: 41717 GeneCards: PPIL3
Gene location (Human)
Chr.	Chromosome 2 (human)
End	200,889,303 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	58,484,645 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; ganglionic eminence; ; secondary oocyte; ; right uterine tube; ; tibialis anterior muscle; ; germinal epithelium; ; tibia; ; lymph node; ; monocyte; ; appendix;
	Top expressed in
	facial motor nucleus; ; hand; ; primitive streak; ; otolith organ; ; utricle; ; superior cervical ganglion; ; medullary collecting duct; ; condyle; ; endocardial cushion; ; blood;
	More reference expression data
	n/a
Gene ontology
Molecular function	isomerase activity; protein binding; peptidyl-prolyl cis-trans isomerase activity;
Cellular component	catalytic step 2 spliceosome; spliceosomal complex;
Biological process	mRNA splicing, via spliceosome; mRNA processing; protein folding; RNA splicing; protein peptidyl-prolyl isomerization;
	Sources:Amigo / QuickGO
Orthologs
	53938
	70225
	ENSG00000240344
	ENSMUSG00000026035
	Q9H2H8
	Q9D6L8
	NM_032472; NM_130906; NM_131916
	NM_001285826; NM_001285827; NM_027351; NM_027374
	NP_115861; NP_570981
	NP_001272755; NP_001272756; NP_081627; NP_081650
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase-like 3 is an enzyme that in humans is encoded by the PPIL3 gene.^[5]^[6]

Function

This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Transcript variants derived from alternative splicing and/or alternative polyadenylation exist; some of these variants encode different isoforms.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000240344 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026035 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhou Z, Ying K, Dai J, Tang R, Wang W, Huang Y, Zhao W, Xie Y, Mao Y (Jul 2001). "Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin)-like gene (PPIL3) from human fetal brain". Cytogenetics and Cell Genetics. 92 (3–4): 231–6. doi:10.1159/000056909. PMID 11435694. S2CID 713529.
1 2 "Entrez Gene: PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3".

Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (Apr 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Huang LL, Zhao XM, Huang CQ, Yu L, Xia ZX (Mar 2005). "Structure of recombinant human cyclophilin J, a novel member of the cyclophilin family". Acta Crystallographica Section D. 61 (Pt 3): 316–21. doi:10.1107/S0907444904033189. PMID 15735342.
Qi ZY, Hui GZ, Li Y, Zhou ZX, Gu SH, Ying K, Xie Y (May 2005). "cDNA microarray in isolation of novel differentially expressed genes related to human glioma and clone of a novel full-length gene". Chinese Medical Journal. 118 (10): 799–805. PMID 15989758.
Hu H, Huang CQ, Liu HL, Han Y, Yu L, Bi RC (Feb 2005). "Crystallization and preliminary X-ray crystallographic studies of human cyclophilin J". Acta Crystallographica Section F. 61 (Pt 2): 216–8. doi:10.1107/S1744309105000643. PMC 1952245. PMID 16510998.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000240344 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026035 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11435694-5] Zhou Z, Ying K, Dai J, Tang R, Wang W, Huang Y, Zhao W, Xie Y, Mao Y (Jul 2001). "Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin)-like gene (PPIL3) from human fetal brain". Cytogenetics and Cell Genetics. 92 (3–4): 231–6. doi:10.1159/000056909. PMID 11435694. S2CID 713529.

[entrez-6] 1 2 "Entrez Gene: PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3".

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Function

References

Further reading