PIGQ
Identifiers
AliasesPIGQ, GPI1, c407A10.1, phosphatidylinositol glycan anchor biosynthesis class Q, EIEE77, DEE77, MCAHS4, GPIBD19
External IDsOMIM: 605754 MGI: 1333114 HomoloGene: 31228 GeneCards: PIGQ
Orthologs
SpeciesHumanMouse
Entrez

9091

14755

Ensembl

ENSG00000007541

ENSMUSG00000025728

UniProt

Q9BRB3

Q9QYT7

RefSeq (mRNA)

NM_148920
NM_004204

NM_001291025
NM_011822
NM_001357592

RefSeq (protein)

NP_004195
NP_683721

NP_001277954
NP_035952
NP_001344521

Location (UCSC)Chr 16: 0.57 – 0.58 MbChr 17: 26.15 – 26.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene.[5][6][7]

This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI).[7]

Interactions

PIGQ has been shown to interact with PIGH,[5] PIGA[5] and PIGC.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000007541 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025728 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 4 Watanabe R, Inoue N, Westfall B, Taron CH, Orlean P, Takeda J, Kinoshita T (Mar 1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1". EMBO J. 17 (4): 877–85. doi:10.1093/emboj/17.4.877. PMC 1170437. PMID 9463366.
  6. Tiede A, Schubert J, Nischan C, Jensen I, Westfall B, Taron CH, Orlean P, Schmidt RE (Nov 1998). "Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants". Biochem J. 334 (3): 609–16. doi:10.1042/bj3340609. PMC 1219730. PMID 9729469.
  7. 1 2 "Entrez Gene: PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q".

Further reading


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