PDCD2
Identifiers
AliasesPDCD2, RP8, ZMYND7, programmed cell death 2
External IDsOMIM: 600866 MGI: 104643 HomoloGene: 1951 GeneCards: PDCD2
Orthologs
SpeciesHumanMouse
Entrez

5134

18567

Ensembl

ENSG00000071994

ENSMUSG00000014771

UniProt

Q16342

P46718

RefSeq (mRNA)

NM_008799

RefSeq (protein)

NP_032825

Location (UCSC)Chr 6: 170.58 – 170.58 MbChr 17: 15.74 – 15.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Programmed cell death protein 2 is a protein that in humans is encoded by the PDCD2 gene.[5][6]

Function

This gene encodes a nuclear protein expressed in a variety of tissues. The rat homolog, Rp8, is transiently expressed in immature thymocytes and is thought to be involved in programmed cell death. Expression of the human gene has been shown to be repressed by BCL6, a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on PDCD2. This gene is closely linked on chromosome 6 to the gene for TBP, the TATA binding protein. Six transcripts encoding different proteins have been identified.[6]

Interactions

PDCD2 has been shown to interact with Host cell factor C1[7] and Parkin (ligase).[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000071994 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014771 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kawakami T, Furukawa Y, Sudo K, Saito H, Takami S, Takahashi E, Nakamura Y (Aug 1995). "Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death". Cytogenetics and Cell Genetics. 71 (1): 41–3. doi:10.1159/000134058. PMID 7606924.
  6. 1 2 "Entrez Gene: PDCD2 programmed cell death 2".
  7. Scarr RB, Sharp PA (Aug 2002). "PDCD2 is a negative regulator of HCF-1 (C1)". Oncogene. 21 (34): 5245–54. doi:10.1038/sj.onc.1205647. PMID 12149646.
  8. Fukae J, Sato S, Shiba K, Sato K, Mori H, Sharp PA, Mizuno Y, Hattori N (Feb 2009). "Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease". FEBS Letters. 583 (3): 521–5. doi:10.1016/j.febslet.2008.12.055. hdl:1721.1/96274. PMID 19146857. S2CID 7121769.

Further reading

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