OGFOD1

OGFOD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NHX, 4NHY
Identifiers
Aliases	OGFOD1, TPA1, 2-oxoglutarate and iron dependent oxygenase domain containing 1
External IDs	OMIM: 615857 MGI: 2442978 HomoloGene: 41238 GeneCards: OGFOD1
Gene location (Human)
Chr.	Chromosome 16 (human)
End	56,479,104 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	94,794,549 bp
RNA expression pattern
	Top expressed in
	oocyte; ; gastrocnemius muscle; ; secondary oocyte; ; biceps brachii; ; tibialis anterior muscle; ; deltoid muscle; ; vastus lateralis muscle; ; stromal cell of endometrium; ; islet of Langerhans; ; Achilles tendon;
	Top expressed in
	ventromedial nucleus; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus; ; superior colliculus; ; ventral tegmental area; ; Region I of hippocampus proper; ; dorsomedial hypothalamic nucleus; ; spermatid; ; otolith organ; ; dorsal tegmental nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	2-oxoglutarate-dependent dioxygenase activity; L-ascorbic acid binding; iron ion binding; oxidoreductase activity; dioxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; peptidyl-proline dioxygenase activity; peptidyl-proline 3-dioxygenase activity; metal ion binding;
Cellular component	cytoplasmic stress granule; nucleus; cytoplasm; cytosol;
Biological process	regulation of translational termination; cell population proliferation; peptidyl-proline hydroxylation; protein hydroxylation; stress granule assembly;
	Sources:Amigo / QuickGO
Orthologs
	55239
	270086
	ENSG00000087263
	ENSMUSG00000033009
	Q8N543
	Q3U0K8
NM_018233; NM_001324357; NM_001324358; NM_001324359; NM_001324360;
	NM_001324361; NM_001324362; NM_001324363
	NM_001093757; NM_177767
NP_001311286; NP_001311287; NP_001311288; NP_001311289; NP_001311290;
	NP_001311291; NP_001311292; NP_060703
	NP_001087226; NP_808435
	Wikidata
View/Edit Human	View/Edit Mouse

2-oxoglutarate and iron-dependent oxygenase domain containing 1, also known as OGFOD1, is a human gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000087263 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033009 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: 2-oxoglutarate and iron-dependent oxygenase domain containing 1". Retrieved 2011-08-30.

Saito K, Adachi N, Koyama H, Matsushita M (Aug 2010). "OGFOD1, a member of the 2-oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling". FEBS Letters. 584 (15): 3340–7. doi:10.1016/j.febslet.2010.06.015. PMID 20579638. S2CID 22010617.
Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Aug 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
Wehner KA, Schütz S, Sarnow P (Apr 2010). "OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress". Molecular and Cellular Biology. 30 (8): 2006–16. doi:10.1128/MCB.01350-09. PMC 2849474. PMID 20154146.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H (Mar 2008). "Toward a confocal subcellular atlas of the human proteome". Molecular & Cellular Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000087263 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033009 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: 2-oxoglutarate and iron-dependent oxygenase domain containing 1". Retrieved 2011-08-30.

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References

Further reading