Narciclasine
Names
Preferred IUPAC name
(2S,3R,4S,4aR)-2,3,4,7-Tetrahydroxy-3,4,4a,5-tetrahydro-9H-[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one
Other names
BRN 1087400, Lycoricidin-A, Lycoricidinol, NSC 266535
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.214.093
KEGG
  • InChI=1S/C14H13NO7/c16-6-1-5-4-2-7-13(22-3-21-7)11(18)8(4)14(20)15-9(5)12(19)10(6)17/h1-2,6,9-10,12,16-19H,3H2,(H,15,20)/t6-,9+,10+,12-/m0/s1
    Key: LZAZURSABQIKGB-AEKGRLRDSA-N
  • InChI=1/C14H13NO7/c16-6-1-5-4-2-7-13(22-3-21-7)11(18)8(4)14(20)15-9(5)12(19)10(6)17/h1-2,6,9-10,12,16-19H,3H2,(H,15,20)/t6-,9+,10+,12-/m0/s1
    Key: LZAZURSABQIKGB-AEKGRLRDBO
  • C1OC2=C(O1)C(=C3C(=C2)C4=C[C@@H]([C@H]([C@H]([C@@H]4NC3=O)O)O)O)O
Properties
C14H13NO7
Molar mass 307.258 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Narciclasine is a toxic alkaloid found in various Amaryllidaceae species.[1]

References

  1. Kornienko A, Evidente A (2008). "Chemistry, biology, and medicinal potential of narciclasine and its congeners". Chem Rev. 108 (6): 1982–2014. doi:10.1021/cr078198u. PMC 2856661. PMID 18489166.

Bibliography

  • Gwendoline Van Goietsenoven; Véronique Mathieu; Florence Lefranc; Alexander Kornienko; Antonio Evidente; Robert Kiss (March 2013). "Narciclasine as well as other Amaryllidaceae Isocarbostyrils are Promising GTP-ase Targeting Agents against Brain Cancers". Medicinal Research Reviews. 33 (2): 439–455. doi:10.1002/med.21253.


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