NSFL1C
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNSFL1C, P47, UBX1, UBXD10, UBXN2C, dJ776F14.1, NSFL1 cofactor
External IDsOMIM: 606610 MGI: 3042273 HomoloGene: 41114 GeneCards: NSFL1C
Orthologs
SpeciesHumanMouse
Entrez

55968

386649

Ensembl

ENSG00000088833

ENSMUSG00000027455

UniProt

Q9UNZ2

Q9CZ44

RefSeq (mRNA)

NM_001206736
NM_016143
NM_018839
NM_182483

NM_001291074
NM_198326

RefSeq (protein)

NP_001193665
NP_057227
NP_061327

NP_001278003
NP_938085

Location (UCSC)Chr 20: 1.44 – 1.47 MbChr 2: 151.34 – 151.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NSFL1 cofactor p47 is a protein that in humans is encoded by the NSFL1C gene.[5][6]

N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Multiple transcript variants encoding several different isoforms have been found for this gene.[6]

Interactions

NSFL1C has been shown to interact with Valosin-containing protein.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000088833 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027455 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  6. 1 2 "Entrez Gene: NSFL1C NSFL1 (p97) cofactor (p47)".
  7. Uchiyama, Keiji; Jokitalo Eija; Lindman Mervi; Jackman Mark; Kano Fumi; Murata Masayuki; Zhang Xiaodong; Kondo Hisao (Jun 2003). "The localization and phosphorylation of p47 are important for Golgi disassembly–assembly during the cell cycle". J. Cell Biol. United States. 161 (6): 1067–79. doi:10.1083/jcb.200303048. ISSN 0021-9525. PMC 2173005. PMID 12810701.

Further reading

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