| NOM1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | NOM1, C7orf3, PPP1R113, SGD1, nucleolar protein with MIF4G domain 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 611269 MGI: 1861749 HomoloGene: 39776 GeneCards: NOM1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Nucleolar protein with MIF4G domain 1 is a protein that in humans is encoded by the NOM1 gene.[5]
Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Simmons et al., 2005 Simmons, HM; Ruis, BL; Kapoor, M; Hudacek, AW; Conklin, KF (February 2005). "Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia". Gene. 347 (1): 137–45. doi:10.1016/j.gene.2004.12.027. PMID 15715967.).[supplied by OMIM].[5]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000146909 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001569 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- 1 2 "Entrez Gene: Nucleolar protein with MIF4G domain 1". Retrieved 2011-09-27.
Further reading
- Heus, H. C.; Hing, A.; Van Baren, M. J.; Joosse, M.; Breedveld, G. J.; Wang, J. C.; Burgess, A.; Donnis-Keller, H.; Berglund, C.; Zguricas, J.; Scherer, S. W.; Rommens, J. M.; Oostra, B. A.; Heutink, P. (1999). "A Physical and Transcriptional Map of the Preaxial Polydactyly Locus on Chromosome 7q36". Genomics. 57 (3): 342–351. doi:10.1006/geno.1999.5796. PMID 10329000.
- Simmons, H. M.; Ruis, B. L.; Kapoor, M.; Hudacek, A. W.; Conklin, K. F. (2005). "Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia". Gene. 347 (1): 137–145. doi:10.1016/j.gene.2004.12.027. PMID 15715967.
- Gunawardena, S. R.; Ruis, B. L.; Meyer, J. A.; Kapoor, M.; Conklin, K. F. (2007). "NOM1 Targets Protein Phosphatase I to the Nucleolus". Journal of Biological Chemistry. 283 (1): 398–404. doi:10.1074/jbc.M706708200. PMID 17965019.
- Alexandrov, A.; Colognori, D.; Steitz, J. A. (2011). "Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex". Genes & Development. 25 (10): 1078–1090. doi:10.1101/gad.2045411. PMC 3093123. PMID 21576267.
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