| MIR499A | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MIR499A, MIR499, MIRN499, hsa-mir-499a, mir-499a, microRNA 499a | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 613614 GeneCards: MIR499A | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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MicroRNA 499a is a non-coding RNA that in humans is encoded by the MIR499A gene.[3]
Function
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000207635 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: MicroRNA 499a". Retrieved 2017-06-02.
Further reading
- Xu J, Hu Z, Xu Z, Gu H, Yi L, Cao H, Chen J, Tian T, Liang J, Lin Y, Qiu W, Ma H, Shen H, Chen Y (2009). "Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population". Hum. Mutat. 30 (8): 1231–6. doi:10.1002/humu.21044. PMID 19514064. S2CID 8131503.
- Catucci I, Yang R, Verderio P, Pizzamiglio S, Heesen L, Hemminki K, Sutter C, Wappenschmidt B, Dick M, Arnold N, Bugert P, Niederacher D, Meindl A, Schmutzler RK, Bartram CC, Ficarazzi F, Tizzoni L, Zaffaroni D, Manoukian S, Barile M, Pierotti MA, Radice P, Burwinkel B, Peterlongo P (2010). "Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases". Hum. Mutat. 31 (1): E1052–7. doi:10.1002/humu.21141. PMID 19847796. S2CID 37236204.
- Wang M, Ye Y, Qian H, Song Z, Jia X, Zhang Z, Zhou J, Ni C (2010). "Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis". J. Hum. Genet. 55 (1): 13–17. doi:10.1038/jhg.2009.112. PMID 19881472.
- Sluijter JP, van Mil A, van Vliet P, Metz CH, Liu J, Doevendans PA, Goumans MJ (2010). "MicroRNA-1 and -499 regulate differentiation and proliferation in human-derived cardiomyocyte progenitor cells". Arterioscler. Thromb. Vasc. Biol. 30 (4): 859–68. doi:10.1161/ATVBAHA.109.197434. PMID 20081117.
- Bell ML, Buvoli M, Leinwand LA (2010). "Uncoupling of expression of an intronic microRNA and its myosin host gene by exon skipping". Mol. Cell. Biol. 30 (8): 1937–45. doi:10.1128/MCB.01370-09. PMC 2849460. PMID 20154144.
- Zhou B, Rao L, Peng Y, Wang Y, Chen Y, Song Y, Zhang L (2010). "Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy". Clin. Chim. Acta. 411 (17–18): 1287–90. doi:10.1016/j.cca.2010.05.010. PMID 20488170.
- Liu Z, Li G, Wei S, Niu J, El-Naggar AK, Sturgis EM, Wei Q (2010). "Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck". Cancer. 116 (20): 4753–60. doi:10.1002/cncr.25323. PMC 3030480. PMID 20549817.
- Wilson KD, Hu S, Venkatasubrahmanyam S, Fu JD, Sun N, Abilez OJ, Baugh JJ, Jia F, Ghosh Z, Li RA, Butte AJ, Wu JC (2010). "Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: role for miR-499". Circ Cardiovasc Genet. 3 (5): 426–35. doi:10.1161/CIRCGENETICS.109.934281. PMC 3057038. PMID 20733065.
- George GP, Gangwar R, Mandal RK, Sankhwar SN, Mittal RD (2011). "Genetic variation in microRNA genes and prostate cancer risk in North Indian population". Mol. Biol. Rep. 38 (3): 1609–15. doi:10.1007/s11033-010-0270-4. PMID 20842445. S2CID 42713060.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.