MGST3

MGST3
Identifiers
Aliases	MGST3, GST-III, microsomal glutathione S-transferase 3
External IDs	OMIM: 604564 MGI: 1913697 HomoloGene: 3327 GeneCards: MGST3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	165,661,796 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	167,221,410 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; jejunal mucosa; ; pons; ; right ventricle; ; thoracic diaphragm; ; duodenum; ; left ventricle; ; prefrontal cortex; ; triceps brachii muscle; ; spongy bone;
	Top expressed in
	mucous cell of stomach; ; epithelium of stomach; ; pyloric antrum; ; olfactory epithelium; ; digastric muscle; ; temporal muscle; ; right ventricle; ; interventricular septum; ; duodenum; ; soleus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein binding; glutathione transferase activity; leukotriene-C4 synthase activity; glutathione peroxidase activity; oxidoreductase activity; lyase activity;
Cellular component	integral component of membrane; organelle membrane; extracellular exosome; endoplasmic reticulum membrane; nuclear envelope; endoplasmic reticulum; membrane; intracellular membrane-bounded organelle;
Biological process	xenobiotic metabolic process; glutathione derivative biosynthetic process; response to organonitrogen compound; cellular oxidant detoxification; lipid metabolism; leukotriene biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	4259
	66447
	ENSG00000143198
	ENSMUSG00000026688
	O14880
	Q9CPU4
	NM_004528
	NM_025569; NM_029392
	NP_004519
	NP_079845
	Wikidata
View/Edit Human	View/Edit Mouse

Microsomal glutathione S-transferase 3 is an enzyme that in humans is encoded by the MGST3 gene.^[5]^[6]

The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143198 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026688 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW (Oct 1997). "Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities". J Biol Chem. 272 (36): 22934–9. doi:10.1074/jbc.272.36.22934. PMID 9278457.
1 2 "Entrez Gene: MGST3 microsomal glutathione S-transferase 3".

Jakobsson PJ, Morgenstern R, Mancini J, et al. (2000). "Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily". Am. J. Respir. Crit. Care Med. 161 (2 Pt 2): S20–4. doi:10.1164/ajrccm.161.supplement_1.ltta-5. PMID 10673221.
Kobayashi K, Xin Y, Ymer SI, et al. (2007). "Subtractive hybridisation screen identifies genes regulated by glucose deprivation in human neuroblastoma cells". Brain Res. 1170: 129–39. doi:10.1016/j.brainres.2007.07.042. PMID 17719568. S2CID 31320196.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Thameem F, Yang X, Permana PA, et al. (2003). "Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians". Hum. Genet. 113 (4): 353–8. doi:10.1007/s00439-003-0980-y. PMID 12898215. S2CID 105953.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000143198 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026688 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9278457-5] Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW (Oct 1997). "Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities". J Biol Chem. 272 (36): 22934–9. doi:10.1074/jbc.272.36.22934. PMID 9278457.

[entrez-6] 1 2 "Entrez Gene: MGST3 microsomal glutathione S-transferase 3".

[1]

[2]

[3]

[4]

[5]

[6]

References

Further reading