ME2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesME2, ODS1, malic enzyme 2
External IDsOMIM: 154270 MGI: 2147351 HomoloGene: 37615 GeneCards: ME2
Orthologs
SpeciesHumanMouse
Entrez

4200

107029

Ensembl

ENSG00000082212

n/a

UniProt

P23368

Q99KE1

RefSeq (mRNA)

NM_001168335
NM_002396

NM_145494

RefSeq (protein)

NP_001161807
NP_002387

NP_663469

Location (UCSC)Chr 18: 50.88 – 50.95 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

NAD-dependent malic enzyme, mitochondrial is a protein that in humans is encoded by the ME2 gene.[4][5] This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000082212 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Loeber G, Infante AA, Maurer-Fogy I, Krystek E, Dworkin MB (Mar 1991). "Human NAD(+)-dependent mitochondrial malic enzyme. cDNA cloning, primary structure, and expression in Escherichia coli". J Biol Chem. 266 (5): 3016–21. doi:10.1016/S0021-9258(18)49948-6. PMID 1993674.
  5. 1 2 "Entrez Gene: ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial".

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.