MCT-1

MCTS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3R90
Identifiers
Aliases	MCTS1, MCT-1, MCT1, malignant T-cell amplified sequence 1, re-initiation and release factor, MCTS1 re-initiation and release factor
External IDs	OMIM: 300587 MGI: 1916245 HomoloGene: 5803 GeneCards: MCTS1
Gene location (Human)
Chr.	X chromosome (human)
End	120,621,159 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	37,702,303 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; body of pancreas; ; prefrontal cortex; ; ganglionic eminence; ; stromal cell of endometrium; ; pituitary gland; ; anterior pituitary; ; thymus; ; right adrenal gland; ; superior frontal gyrus;
	Top expressed in
	facial motor nucleus; ; barrel cortex; ; superior cervical ganglion; ; anterior horn of spinal cord; ; medial ganglionic eminence; ; sternocleidomastoid muscle; ; soleus muscle; ; dermis; ; triceps brachii muscle; ; brown adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	translation initiation factor activity; RNA binding; protein binding;
Cellular component	plasma membrane; cytosolic small ribosomal subunit; cytoplasm; cytosol;
Biological process	translational initiation; cell cycle; regulation of growth; regulation of transcription, DNA-templated; ribosome disassembly; protein biosynthesis; formation of translation preinitiation complex; transcription, DNA-templated; positive regulation of cell population proliferation; cellular response to DNA damage stimulus; translation reinitiation; IRES-dependent viral translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	28985
	68995
	ENSG00000232119; ENSG00000288295
	ENSMUSG00000000355
	Q9ULC4
	Q9DB27
	NM_001137554; NM_014060
	NM_026902; NM_001356359; NM_001356360; NM_001361381; NM_001361382
	NP_001131026; NP_054779
	NP_081178; NP_001343288; NP_001343289; NP_001348310; NP_001348311
	Wikidata
View/Edit Human	View/Edit Mouse

MCTS1, re-initiation and release factor, otherwise known as MCT-1, is a protein that in humans is encoded by the MCTS1 gene. ^[5]

References

1 2 3 ENSG00000288295 GRCh38: Ensembl release 89: ENSG00000232119, ENSG00000288295 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000355 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MCTS1, re-initiation and release factor". Retrieved 2018-01-01.

Shi B, Hsu HL, Evens AM, Gordon LI, Gartenhaus RB (2003). "Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies". Blood. 102 (1): 297–302. doi:10.1182/blood-2002-11-3486. PMID 12637315.
Shi B, Levenson V, Gartenhaus RB (2003). "Identification and characterization of a novel enhancer for the human MCT-1 oncogene promoter". J. Cell. Biochem. 90 (1): 68–79. doi:10.1002/jcb.10609. PMID 12938157. S2CID 31678534.
Mazan-Mamczarz K, Hagner P, Dai B, Corl S, Liu Z, Gartenhaus RB (2009). "Targeted suppression of MCT-1 attenuates the malignant phenotype through a translational mechanism". Leuk. Res. 33 (3): 474–82. doi:10.1016/j.leukres.2008.08.012. PMID 18824261.
Kasiappan R, Shih HJ, Chu KL, Chen WT, Liu HP, Huang SF, Choy CO, Shu CL, Din R, Chu JS, Hsu HL (2009). "Loss of p53 and MCT-1 overexpression synergistically promote chromosome instability and tumorigenicity". Mol. Cancer Res. 7 (4): 536–48. doi:10.1158/1541-7786.MCR-08-0422. PMID 19372582.
Pérez-Arellano I, Gozalbo-Rovira R, Martínez AI, Cervera J (2010). "Expression and purification of recombinant human MCT-1 oncogene in insect cells". Protein J. 29 (2): 69–74. doi:10.1007/s10930-009-9223-y. PMID 20076993. S2CID 5299658.
Chen H, Wang L, Beretov J, Hao J, Xiao W, Li Y (2010). "Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression". Clin. Exp. Metastasis. 27 (8): 557–69. doi:10.1007/s10585-010-9345-9. PMID 20658178. S2CID 26525740.
Narumi K, Furugen A, Kobayashi M, Otake S, Itagaki S, Iseki K (2010). "Regulation of monocarboxylate transporter 1 in skeletal muscle cells by intracellular signaling pathways". Biol. Pharm. Bull. 33 (9): 1568–73. doi:10.1248/bpb.33.1568. PMID 20823576.
Kasiappan R, Shih HJ, Wu MH, Choy C, Lin TD, Chen L, Hsu HL (2010). "The antagonism between MCT-1 and p53 affects the tumorigenic outcomes". Mol. Cancer. 9: 311. doi:10.1186/1476-4598-9-311. PMC 3019166. PMID 21138557.
Shih HJ, Chu KL, Wu MH, Wu PH, Chang WW, Chu JS, Wang LH, Takeuchi H, Ouchi T, Hsu HL (2012). "The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities". Cell Cycle. 11 (5): 934–52. doi:10.4161/cc.11.5.19452. PMID 22336915.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000288295 GRCh38: Ensembl release 89: ENSG00000232119, ENSG00000288295 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000355 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MCTS1, re-initiation and release factor". Retrieved 2018-01-01.

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See also

References

Further reading