MAP4K5
Identifiers
AliasesMAP4K5, GCKR, KHS, KHS1, MAPKKKK5, mitogen-activated protein kinase kinase kinase kinase 5
External IDsOMIM: 604923 MGI: 1925503 HomoloGene: 38199 GeneCards: MAP4K5
Orthologs
SpeciesHumanMouse
Entrez

11183

399510

Ensembl

ENSG00000012983

ENSMUSG00000034761

UniProt

Q9Y4K4

Q8BPM2

RefSeq (mRNA)

NM_006575
NM_198794

NM_201519

RefSeq (protein)

NP_006566
NP_942089

NP_958927

Location (UCSC)Chr 14: 50.42 – 50.56 MbChr 12: 69.85 – 69.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitogen-activated protein kinase kinase kinase kinase 5 is an enzyme that in humans is encoded by the MAP4K5 gene.[5][6][7]

This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[7]

Interactions

MAP4K5 has been shown to interact with CRKL[8] and TRAF2.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000012983 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034761 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tung RM, Blenis J (March 1997). "A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase". Oncogene. 14 (6): 653–9. doi:10.1038/sj.onc.1200877. PMID 9038372.
  6. Schultz SJ, Nigg EA (February 1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
  7. 1 2 "Entrez Gene: MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5".
  8. Shi CS, Tuscano J, Kehrl J H (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation". Blood. UNITED STATES. 95 (3): 776–82. doi:10.1182/blood.V95.3.776.003k23_776_782. ISSN 0006-4971. PMID 10648385. S2CID 22593342.
  9. Shi CS, Leonardi A, Kyriakis J, Siebenlist U, Kehrl J H (September 1999). "TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related". J. Immunol. UNITED STATES. 163 (6): 3279–85. doi:10.4049/jimmunol.163.6.3279. ISSN 0022-1767. PMID 10477597.

Further reading


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