| LDOC1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | LDOC1, BCUR1, Mar7, Mart7, leucine zipper, down-regulated in cancer 1, regulator of NFKB signaling, SIRH7, RTL7, LDOC1 regulator of NFKB signaling | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 300402 MGI: 2685212 HomoloGene: 32153 GeneCards: LDOC1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Protein LDOC1 is a protein that in humans is encoded by the LDOC1 gene.[5][6][7][8]
Function
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.[8]
Interactions
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000182195 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057615 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Nagasaki K, Manabe T, Hanzawa H, Maass N, Tsukada T, Yamaguchi K (Jun 1999). "Identification of a novel gene, LDOC1, down-regulated in cancer cell lines". Cancer Letters. 140 (1–2): 227–34. doi:10.1016/S0304-3835(99)00087-7. PMID 10403563.
- ↑ Brandt J, Schrauth S, Veith AM, Froschauer A, Haneke T, Schultheis C, Gessler M, Leimeister C, Volff JN (Jan 2005). "Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals". Gene. 345 (1): 101–11. doi:10.1016/j.gene.2004.11.022. PMID 15716091.
- ↑ Brandt J, Veith AM, Volff JN (Aug 2005). "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes". Cytogenetic and Genome Research. 110 (1–4): 307–17. doi:10.1159/000084963. PMID 16093683. S2CID 38398479.
- 1 2 "Entrez Gene: LDOC1 leucine zipper, down-regulated in cancer 1".
- ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Further reading
- Nagasaki K, Schem C, von Kaisenberg C, Biallek M, Rösel F, Jonat W, Maass N (Jul 2003). "Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis". International Journal of Cancer. 105 (4): 454–8. doi:10.1002/ijc.11122. PMID 12712434.
- Chih DY, Park DJ, Gross M, Idos G, Vuong PT, Hirama T, Chumakov AM, Said J, Koeffler HP (Dec 2004). "Protein partners of C/EBPepsilon". Experimental Hematology. 32 (12): 1173–81. doi:10.1016/j.exphem.2004.08.014. PMID 15588942.
- Inoue M, Takahashi K, Niide O, Shibata M, Fukuzawa M, Ra C (Jan 2005). "LDOC1, a novel MZF-1-interacting protein, induces apoptosis". FEBS Letters. 579 (3): 604–8. doi:10.1016/j.febslet.2004.12.030. PMID 15670815.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
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