LCTL
Identifiers
AliasesLCTL, KLG, KLPH, lactase like
External IDsOMIM: 617060 MGI: 2183549 HomoloGene: 70710 GeneCards: LCTL
Orthologs
SpeciesHumanMouse
Entrez

197021

235435

Ensembl

ENSG00000188501

ENSMUSG00000032401

UniProt

Q6UWM7

Q8K1F9

RefSeq (mRNA)

NM_001278562
NM_207338
NM_001394632
NM_001394633

NM_145835

RefSeq (protein)

NP_001265491
NP_997221

NP_665834

Location (UCSC)Chr 15: 66.55 – 66.57 MbChr 9: 64.02 – 64.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lactase-like is a protein that in humans is encoded by the LCTL gene.[5] Lactase-like is a glycosidase enzyme.

Function

This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000188501 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032401 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Lactase-like". Retrieved 2013-09-25.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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