LASP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLASP1, MLN50, LIM and SH3 protein 1, LASP-1
External IDsOMIM: 602920 MGI: 109656 HomoloGene: 4480 GeneCards: LASP1
Orthologs
SpeciesHumanMouse
Entrez

3927

16796

Ensembl

ENSG00000002834

ENSMUSG00000038366

UniProt

Q14847

Q61792

RefSeq (mRNA)

NM_001271608
NM_006148

NM_010688

RefSeq (protein)

NP_001258537
NP_006139

NP_034818

Location (UCSC)Chr 17: 38.87 – 38.92 MbChr 11: 97.69 – 97.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LIM and SH3 domain protein 1 is a protein that in humans is encoded by the LASP1 gene.[5][6]

This gene encodes a member of a LIM protein subfamily which is characterized by a LIM motif and a domain of Src homology region 3. This protein functions as an actin-binding protein and possibly in cytoskeletal organization.[6]

Interactions

LASP1 has been shown to interact with Zyxin.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000002834 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038366 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC (Jan 1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics. 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069.
  6. 1 2 "Entrez Gene: LASP1 LIM and SH3 protein 1".
  7. Li B, Zhuang Lei, Trueb Beat (May 2004). "Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1". J. Biol. Chem. United States. 279 (19): 20401–10. doi:10.1074/jbc.M310304200. ISSN 0021-9258. PMID 15004028.

Further reading


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