H3C11
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH3C11, H3.f, H3/f, H3FF, histone cluster 1, H3i, histone cluster 1 H3 family member i, H3 clustered histone 11, HIST1H3I, H3C4, H3C7, H3C12, H3C2, H3C8, H3C10, H3C3, H3C6, H3C1
External IDsOMIM: 602814 MGI: 2448326 HomoloGene: 134496 GeneCards: H3C11
Orthologs
SpeciesHumanMouse
Entrez

8354

319151

Ensembl

ENSG00000275379

ENSMUSG00000069273

UniProt

P68431

P84228

RefSeq (mRNA)

NM_003533

NM_178205

RefSeq (protein)

NP_066298
NP_003520
NP_003525
NP_003527

Location (UCSC)Chr 6: 27.87 – 27.87 MbChr 13: 23.75 – 23.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H3.1 is a protein that in humans is encoded by the HIST1H3I gene.[5][6][7][8]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000275379 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000069273 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Albig W, Meergans T, Doenecke D (January 1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene. 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620.
  6. Albig W, Doenecke D (December 1997). "The human histone gene cluster at the D6S105 locus". Human Genetics. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
  7. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (November 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  8. 1 2 "Entrez Gene: HIST1H3I histone cluster 1, H3i".

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.