GADD45GIP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGADD45GIP1, CKBBP2, CKbetaBP2, CRIF1, MRP-L59, PLINP, PLINP-1, PRG6, Plinp1, GADD45G interacting protein 1
External IDsOMIM: 605162 MGI: 1914947 HomoloGene: 33474 GeneCards: GADD45GIP1
Orthologs
SpeciesHumanMouse
Entrez

90480

102060

Ensembl

ENSG00000179271

ENSMUSG00000033751

UniProt

Q8TAE8

Q9CR59

RefSeq (mRNA)

NM_052850

NM_183358

RefSeq (protein)

NP_443082

NP_899202

Location (UCSC)Chr 19: 12.95 – 12.96 MbChr 8: 85.56 – 85.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Growth arrest and DNA-damage-inducible proteins-interacting protein 1 is a protein that in humans is encoded by the GADD45GIP1 gene.[5][6][7]

GADD45GIP1, also known as CRIF1 is newly identified de novo components in large subunit of mitoribosome. It is essential for the translation of mitochondrial oxidative phosphorylation (OXPHOS) polypeptides in mammalian mitochondria. CRIF1 interacts with low-sulfur (LSU) proteins, some of which surround the exit tunnel of the mitoribosome, and also interacts with nascent OXPHOS polypeptides and the mitochondrial-specific chaperone Tid1. The essential role of CRIF1 in mitochondrial synthesis and membrane integration of OXPHOS polypeptides was shown in brain-specific CRIF1-deficient mice, which exhibited profound OXPHOS failure and marked neurodegeneration.[8]

Interactions

GADD45GIP1 has been shown to interact with GADD45G,[9] GADD45B[9] and GADD45A.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000179271 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033751 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Horikoshi N, Cong J, Kley N, Shenk T (Aug 1999). "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene". Biochemical and Biophysical Research Communications. 261 (3): 864–9. doi:10.1006/bbrc.1999.1123. PMID 10441517.
  6. Görnemann J, Hofmann TG, Will H, Müller M (Nov 2002). "Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins". Virology. 303 (1): 69–78. doi:10.1006/viro.2002.1670. PMID 12482659.
  7. "Entrez Gene: GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1".
  8. Kim SJ, Kwon M, Ryu MJ, Chung HK, Tadi S, Kim YK, et al. (2012). "CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane". Cell Metabolism. 16 (2): 274–283. doi:10.1016/j.cmet.2012.06.012. ISSN 1550-4131. PMID 22819524.
  9. 1 2 3 Chung HK, Yi YW, Jung NC, Kim D, Suh JM, Kim H, Park KC, Song JH, Kim DW, Hwang ES, Yoon SH, Bae YS, Kim JM, Bae I, Shong M (Jul 2003). "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle". The Journal of Biological Chemistry. 278 (30): 28079–88. doi:10.1074/jbc.M212835200. PMID 12716909.

Further reading

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