FPGS
Identifiers
AliasesFPGS, folylpolyglutamate synthase
External IDsOMIM: 136510 MGI: 95576 HomoloGene: 6997 GeneCards: FPGS
Orthologs
SpeciesHumanMouse
Entrez

2356

14287

Ensembl

ENSG00000136877

ENSMUSG00000009566

UniProt

Q05932

P48760

RefSeq (mRNA)

NM_001018078
NM_001288803
NM_004957

NM_010236

RefSeq (protein)

NP_001018088
NP_001275732
NP_004948

NP_034366

Location (UCSC)Chr 9: 127.79 – 127.81 MbChr 2: 32.57 – 32.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Folylpolyglutamate synthase, mitochondrial is an enzyme that in humans is encoded by the FPGS gene.[5]

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms.[5]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

[[File:
FluoropyrimidineActivity_WP1601
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FluoropyrimidineActivity_WP1601
|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000136877 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000009566 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: FPGS folylpolyglutamate synthase".

Further reading


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