FZD6
Identifiers
AliasesFZD6, FZ-6, FZ6, HFZ6, NDNC10, frizzled class receptor 6, NDNC1
External IDsOMIM: 603409 MGI: 108474 HomoloGene: 2617 GeneCards: FZD6
Orthologs
SpeciesHumanMouse
Entrez

8323

14368

Ensembl

ENSG00000164930

ENSMUSG00000022297

UniProt

O60353

Q61089

RefSeq (mRNA)

NM_001164615
NM_001164616
NM_003506
NM_001317796

NM_001162494
NM_008056

RefSeq (protein)

NP_001155966
NP_032082

Location (UCSC)Chr 8: 103.3 – 103.33 MbChr 15: 38.87 – 38.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Frizzled-6 (Fz-6) is a protein that in humans is encoded by the FZD6 gene.[5][6][7]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif.[7] Fz-6 is believed to be the receptor for the WNT4 ligand.[8]

Interactions

Fz-6 has been shown to interact with secreted frizzled-related protein 1.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000164930 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022297 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tokuhara M, Hirai M, Atomi Y, Terada M, Katoh M (Feb 1998). "Molecular cloning of human Frizzled-6". Biochemical and Biophysical Research Communications. 243 (2): 622–7. doi:10.1006/bbrc.1998.8143. PMID 9480858.
  6. Golan T, Yaniv A, Bafico A, Liu G, Gazit A (Apr 2004). "The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade". The Journal of Biological Chemistry. 279 (15): 14879–88. doi:10.1074/jbc.M306421200. PMID 14747478.
  7. 1 2 "Entrez Gene: FZD6 frizzled homolog 6 (Drosophila)".
  8. Lyons JP, Mueller UW, Ji H, Everett C, Fang X, Hsieh JC, Barth AM, McCrea PD (Aug 2004). "Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells". Experimental Cell Research. 298 (2): 369–87. doi:10.1016/j.yexcr.2004.04.036. PMID 15265686.
  9. Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA (Jun 1999). "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". The Journal of Biological Chemistry. 274 (23): 16180–7. doi:10.1074/jbc.274.23.16180. PMID 10347172.

Further reading

  • "Frizzled Receptors: FZD6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

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