FLII
Identifiers
AliasesFLII, FLI, FLIL, Fli1, actin remodeling protein, FLII actin remodeling protein
External IDsOMIM: 600362 MGI: 1342286 HomoloGene: 11092 GeneCards: FLII
Orthologs
SpeciesHumanMouse
Entrez

2314

14248

Ensembl

ENSG00000177731
ENSG00000284571

ENSMUSG00000002812

UniProt

Q13045

Q9JJ28

RefSeq (mRNA)

NM_001256264
NM_001256265
NM_002018

NM_022009
NM_001302207

RefSeq (protein)

NP_001243193
NP_001243194
NP_002009

NP_001289136
NP_071292

Location (UCSC)Chr 17: 18.24 – 18.26 MbChr 11: 60.6 – 60.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein flightless-1 homolog is a protein that in humans is encoded by the FLII gene.[5][6]

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain.[7] The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.[6]

Interactions

FLII has been shown to interact with LRRFIP1[8][9] and TRAF interacting protein.[10]

References

  1. 1 2 3 ENSG00000284571 GRCh38: Ensembl release 89: ENSG00000177731, ENSG00000284571 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002812 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen KS, Gunaratne PH, Hoheisel JD, Young IG, Miklos GL, Greenberg F, Shaffer LG, Campbell HD, Lupski JR (Feb 1995). "The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2". Am J Hum Genet. 56 (1): 175–82. PMC 1801336. PMID 7825574.
  6. 1 2 "Entrez Gene: FLII flightless I homolog (Drosophila)".
  7. Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.
  8. Liu, Y T; Yin H L (Apr 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. ISSN 0021-9258. PMID 9525888.
  9. Fong, K S; de Couet H G (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. ISSN 0888-7543. PMID 10366446.
  10. Wilson, S A; Brown E C; Kingsman A J; Kingsman S M (Aug 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. ISSN 0305-1048. PMC 147727. PMID 9671805.

Further reading


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