FADS1
Identifiers
AliasesFADS1, D5D, FADS6, FADSD5, LLCDL1, TU12, fatty acid desaturase 1
External IDsOMIM: 606148 MGI: 1923517 HomoloGene: 22753 GeneCards: FADS1
Orthologs
SpeciesHumanMouse
Entrez

3992

76267

Ensembl

ENSG00000149485

ENSMUSG00000010663

UniProt

O60427

Q920L1

RefSeq (mRNA)

NM_013402

NM_146094

RefSeq (protein)

NP_037534

NP_666206

Location (UCSC)Chr 11: 61.8 – 61.83 MbChr 19: 10.16 – 10.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fatty acid desaturase 1 (FADS1) is an enzyme that in humans is encoded by the FADS1 gene.[5]

Function

The protein encoded by the FADS1 gene is a member of the fatty acid desaturase (FADS) gene family and desaturates omega-3 and omega-6 polyunsaturated fatty acids at the delta-5 position, catalyzing the final step in the formation of eicosapentaenoic acid (EPA) and arachidonic acid.[6] Desaturase enzymes (such as those encoded by FADS1) regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.[5]

Clinical significance

Single nucleotide polymorphisms (SNPs) of FADS1 and FADS2 may affect long-chain polyunsaturated fatty acids (LC-PUFA) metabolism and have a potential role in the development of atopic diseases.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000149485 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010663 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: FADS1 fatty acid desaturase 1".
  6. Brenna, J Thomas (June 2009). "An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Δ8-desaturates 20:2n-6 and 20:3n-3". Journal of Lipid Research. 50 (6): 1195–202. doi:10.1194/jlr.M800630-JLR200. PMC 2681401. PMID 19202133.
  7. Lattka, E.; Illig, T.; Heinrich, J.; Koletzko, B. (2009). "FADS Gene Cluster Polymorphisms: Important Modulators of Fatty Acid Levels and Their Impact on Atopic Diseases". Journal of Nutrigenetics and Nutrigenomics. 2 (3): 119–128. doi:10.1159/000235559. PMID 19776639. S2CID 17077710.

Further reading


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