ENTPD6

ENTPD6
Identifiers
Aliases	ENTPD6, CD39L2, IL-6SAG, IL6ST2, NTPDase-6, dJ738P15.3, ectonucleoside triphosphate diphosphohydrolase 6 (putative), ectonucleoside triphosphate diphosphohydrolase 6
External IDs	OMIM: 603160 MGI: 1202295 HomoloGene: 68170 GeneCards: ENTPD6
Gene location (Human)
Chr.	Chromosome 20 (human)
End	25,228,075 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	150,771,675 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; middle frontal gyrus; ; anterior pituitary; ; caudate nucleus; ; prefrontal cortex; ; Brodmann area 10; ; right adrenal gland; ; Brodmann area 9; ; cingulate gyrus; ; minor salivary gland;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; dorsomedial hypothalamic nucleus; ; subiculum; ; paraventricular nucleus of hypothalamus; ; ventromedial nucleus; ; lateral hypothalamus; ; arcuate nucleus; ; seminal vesicula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleoside-triphosphatase activity; guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity; uridine-diphosphatase activity; hydrolase activity; nucleoside-diphosphatase activity;
Cellular component	integral component of membrane; cell surface; Golgi membrane; plasma membrane; membrane; extracellular region; extracellular space; Golgi apparatus;
Biological process	response to calcium ion; response to magnesium ion; nucleobase-containing small molecule catabolic process; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	955
	12497
	ENSG00000197586
	ENSMUSG00000033068
	O75354; Q5QPI7
	Q3U0P5
NM_001114089; NM_001247; NM_001317941; NM_001322378; NM_001322379;
	NM_001322380; NM_001322381; NM_001322382; NM_001322383; NM_001322384; NM_001322385; NM_001322386; NM_001322387; NM_001322388; NM_001322389; NM_001322390; NM_001322391; NM_001322392; NM_001322393; NM_001322394; NM_001322395; NM_001322396; NM_001322397; NM_001322398
	NM_172117; NM_001355068
NP_001107561; NP_001238; NP_001304870; NP_001309307; NP_001309308;
	NP_001309309; NP_001309310; NP_001309311; NP_001309312; NP_001309313; NP_001309314; NP_001309315; NP_001309316; NP_001309317; NP_001309318; NP_001309319; NP_001309320; NP_001309321; NP_001309322; NP_001309323; NP_001309324; NP_001309325; NP_001309326; NP_001309327
	NP_742115; NP_001341997; NP_001357558; NP_001357559; NP_001357560
	Wikidata
View/Edit Human	View/Edit Mouse

Ectonucleoside triphosphate diphosphohydrolase 6 is an enzyme that in humans is encoded by the ENTPD6 gene.^[5]^[6]

Function

ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions, which is characteristic of NTPases.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197586 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033068 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chadwick BP, Frischauf AM (Jun 1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics. 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID 9676430.
1 2 "Entrez Gene: ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative function)".

Chadwick BP, Frischauf AM (Sep 1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mammalian Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID 9271669. S2CID 42644202.
Hicks-Berger CA, Chadwick BP, Frischauf AM, Kirley TL (Nov 2000). "Expression and characterization of soluble and membrane-bound human nucleoside triphosphate diphosphohydrolase 6 (CD39L2)". The Journal of Biological Chemistry. 275 (44): 34041–5. doi:10.1074/jbc.M004723200. PMID 10948193.
Yeung G, Mulero JJ, McGowan DW, Bajwa SS, Ford JE (Oct 2000). "CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart". Biochemistry. 39 (42): 12916–23. doi:10.1021/bi000959z. PMID 11041856.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Ivanenkov VV, Murphy-Piedmonte DM, Kirley TL (Oct 2003). "Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function". Biochemistry. 42 (40): 11726–35. doi:10.1021/bi035137r. PMID 14529283.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197586 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033068 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9676430-5] Chadwick BP, Frischauf AM (Jun 1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics. 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID 9676430.

[entrez-6] 1 2 "Entrez Gene: ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative function)".

[1]

[2]

[3]

[4]

[5]

[6]

Function

References

Further reading