EIF4ENIF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF4ENIF1, 4E-T, Clast4, eukaryotic translation initiation factor 4E nuclear import factor 1
External IDsOMIM: 607445 MGI: 1921453 HomoloGene: 10522 GeneCards: EIF4ENIF1
Orthologs
SpeciesHumanMouse
Entrez

56478

74203

Ensembl

ENSG00000184708

ENSMUSG00000020454

UniProt

Q9NRA8

Q9EST3

RefSeq (mRNA)

NM_001164501
NM_001164502
NM_019843

NM_001166547
NM_001166548
NM_001166549
NM_023743

RefSeq (protein)

NP_001157973
NP_001157974
NP_062817

NP_001160019
NP_001160020
NP_001160021
NP_076232

Location (UCSC)Chr 22: 31.44 – 31.5 MbChr 11: 3.15 – 3.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic translation initiation factor 4E transporter is a protein that in humans is encoded by the EIF4ENIF1 gene.[5][6]

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic;its own nuclear import is regulated by a nuclear localization signal and nuclear export signals.[6]

Interactions

EIF4ENIF1 has been shown to interact with EIF4E.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000184708 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020454 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Dostie J, Ferraiuolo M, Pause A, Adam SA, Sonenberg N (Aug 2000). "A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E". EMBO J. 19 (12): 3142–56. doi:10.1093/emboj/19.12.3142. PMC 203362. PMID 10856257.
  6. 1 2 "Entrez Gene: EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1".

Further reading


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