DOK6
Identifiers
AliasesDOK6, DOK5L, HsT3226, docking protein 6
External IDsOMIM: 611402 MGI: 3639495 HomoloGene: 45143 GeneCards: DOK6
Orthologs
SpeciesHumanMouse
Entrez

220164

623279

Ensembl

ENSG00000206052

ENSMUSG00000073514

UniProt

Q6PKX4

Q2MHE5

RefSeq (mRNA)

NM_152721

NM_001039173

RefSeq (protein)

NP_689934

NP_001034262

Location (UCSC)Chr 18: 69.4 – 69.85 MbChr 18: 89.31 – 89.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Docking protein 6 is a protein that in humans is encoded by the DOK6 gene. [5]

Function

DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000206052 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000073514 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Docking protein 6". Retrieved 2017-02-01.

Further reading

  • Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.
  • Kurotsuchi A, Murakumo Y, Jijiwa M, Kurokawa K, Itoh Y, Kodama Y, Kato T, Enomoto A, Asai N, Terasaki H, Takahashi M (2010). "Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells". Cancer Sci. 101 (5): 1147–55. doi:10.1111/j.1349-7006.2010.01520.x. PMID 20210798. S2CID 11769638.


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