DNASE2B
Identifiers
AliasesDNASE2B, DLAD, deoxyribonuclease II beta, deoxyribonuclease 2 beta
External IDsOMIM: 608057 MGI: 1913283 HomoloGene: 1052 GeneCards: DNASE2B
Orthologs
SpeciesHumanMouse
Entrez

58511

56629

Ensembl

ENSG00000137976

ENSMUSG00000028185

UniProt

Q8WZ79
Q66K39

Q9QY48

RefSeq (mRNA)

NM_021233
NM_058248

NM_019957

RefSeq (protein)

NP_067056
NP_490649
NP_067056.2

NP_064341

Location (UCSC)Chr 1: 84.4 – 84.42 MbChr 3: 146.29 – 146.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Deoxyribonuclease 2 beta is a protein that in humans is encoded by the DNASE2B gene. [5]

Function

The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000137976 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028185 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Deoxyribonuclease 2 beta". Retrieved 2018-01-31.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.